Therapy for NEMO is aimed at preventing infectious complications. Patients receive immunoglobulin replacement for the humoral immunodeficiency. While a cornerstone of therapy, this is insufficient to control infections given the broad-based immune defects in these patients. Therefore, patients also receive a series of antibiotics as part of their preventive regimen. These antibiotics are aimed at protecting the patients against S. pneumoniae, S. aureus, and mycobacterial infections.
Patients with NEMO should see their primary care physician and immunologist regularly as complications both infectious and otherwise are frequent. Patients with NEMO should also be monitored for bone health as NEMO syndrome patients may be less able to make strong bones (though recurrent fractures have not been a common theme amongst these patients).